If you want to use your NetScaler for all things that need to be accessible from the outside, over a single IP address, that poses an issue. As is usually a problem with small to medium sized businesses which only have one public IP address at their disposal, and need to implement features like a fully functional RDS environment (with RD Web Access, RD Gateway, etc), a XenApp/XenDesktop evnironment with StoreFront, and even AD FS, say, for Office365. Generally all these services require port 443 (https) to be fully functional, and you can only set up one distinctive IP address on your NetScaler providing this service, pointing it to your internal resources via Firewall rules, thus leaving you with only one option: NetScaler's Unified Gateway and Content Switching features.
I came upon this quite frequent issue with my XenDesktop 7.8 Hosted Shared Desktop environment based on Windows Server 2008 R2. Folder Redirection via GPO is in place, whereas Citrix User Profile Management is not used.